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ECVAM publishes status update on alternatives to animal testing

September 1st, 2014

The European Union Reference Laboratory or Alternatives to Animal Testing (EURL ECVAM) has published a status update report communicating current developments in alternatives to animal testing. The report focuses on ECVAM’s activity in 2014 and provides information on the various methods being developed to move away from animal tests, including the areas of fish toxicity, bioconcentration/bioaccumulation, endocrine disruption and irritation. 

The report includes an account of regulatory acceptance of alternative methods and current recommendations by ECVAM. Information is also provided on the status of ongoing validation studies, R&D and peer reviews. The challenge to replace certain methodologies continues, for example repeated dose toxicity testing, where other areas such as irritation testing are better developed.

Different strategy papers address various regulatory areas and endpoints, including genotxicity, acute systemic toxicity, toxicokinetics and environmental fate. Significant progress has been made in the development of alternative methods, which is expected to carry on with the continued support and input from the regulatory and industry key players.